Abstract

LOPEZ, Mónica Patricia; GUETE, Cindi Natali  and  OSPINA, Jacqueline. DETECTION OF Klebsiella pneumoniae STRAINS PRODUCERS OF EXTENDED SPECTRUM BETA-LACTAMASES ISOLATED IN A HIGH COMPLEXITY CLINICAL CENTER IN SANTA MARTA, COLOMBIA. Biosalud [online]. 2015, vol.14, n.2, pp.63-70. ISSN 1657-9550.  https://doi.org/10.17151/biosa.2015.14.2.6.

Introduction: Klebsiella pneumoniae is one of the main microorganisms producing extended spectrum beta-lactamase (ESBL) commonly isolated in clinical centers, becoming the main responsible for opportunistic infectious diseases. Materials and Methods: Strains of K. pneumoniae from any type of biological samples were identified using the API 10E system. ESBLs detection was performed as recommended by the Clinical and Laboratory Standards Institute. Results: Between September 2014 and March 2015, 18 strains of K. pneumoniae produced ESBL and exhibited a phenotypic pattern characterized by resistance to aminopenicillins ureidopenicillins, carboxypenicillins and cephalosporins of first, second and third generation. They also showed resistance to combinations with bectalactamases inhibitors as well as to some aminoglycosides such as tobramycin, gentamicin and netilmicin, maintaining sensitivity to amikacin, trimethoprim/sulfamethoxazole, quinolones and carbapenems. Discussion: The prevalence of K. pneumoniae strains producing ESBL was similar to that reported in other cities of Colombia, differing in the resistance exhibited against beta-lactamase and carbapenems inhibitors, although in lower percentages for the latter, and emphasizing high sensitivity to amikacin.

Keywords : B-lactamases; Klebsiella pneumoniae; producers; resistance.

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