Abstract

PINZON, Carlos Eduardo; SERRANO, Martha Lucía  and  SANABRIA, María Carolina. Role of phosphatidylinositol 3-kinase pathway (PI3K/Akt) in humans. Rev. Cienc. Salud [online]. 2009, vol.7, n.2, pp.47-66. ISSN 1692-7273.

The signaling pathway of phosphatidylinositol 3-kinase (PI3K) is critical in many aspects of growth and cell survival. The path of PI3K is stimulated physiologically as a result of many growth factors and regulatory factors. Several genetic alterations such as amplification, mutation and chromosomal arrangements may compromise the PI3K pathway, generating permanent activation in different cancer types have found evidence of these deleterious genetic modifications. Abnormal activation of the PI3K pathway results in alteration of the control mechanisms of growth and cell survival, which favors the competitive growth, and frequently metastatic capacity, greater resistance to treatment. The aim of this paper is to review matters relating to the operation of the PI3K/Akt signaling pathway and its role in the process of carcinogenesis in humans.

Keywords : 1-Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; m TOR protein; neoplasm.

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