Abstract

JUTINICO-SHUBACH, Adriana Paola; GONZALEZ-DEVIA, Johanna Lizeth  and  SANCHEZ-MORA, Ruth Mélida. Association between Hsp60 of Chlamydia trachomatis and ovarian cancer. Nova [online]. 2017, vol.15, n.28, pp.57-68. ISSN 1794-2470.

Heat Shock Proteins are a family of highly conserved proteins and their expression is regulated by exposure to stress conditions. Chlamydia trachomatis is an obligate intracellular bacterium, sexually transmitted that causes chronic and persistent infection, which enables the expression of HSP-like protein as HSP60 Chlamydial (cHSP60). cHSP60 shares 50% homology with human protein. This review shows imunoepidemiological studies that have demonstrated an association between the immune response to cHSP60 and sequelae of CT infection generated by chronic inflammation. One of those sequelae is probably the development of ovarian cancer, a pathology that according to WHO is one deadliest gynaecologic cancer and the fifth leading cause of cancer dead among women. In this review, we discuss how cHSP60 causes a prolonged antibody response as a source of antigenic stimulation and chronic inflammation due to cross reactivity with human antigens and its association with the development of ovarian cancer.

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