Abstract

CIRO GALEANO, Johana Andrea; LOPEZ HERRERA, Albeiro  and  PARRA SUESCUN, Jaime. Molecular expression of villin in jejunum of weaned pigs after oral intake of LPS from E. coli. Ces. Med. Vet. Zootec. [online]. 2013, vol.8, n.2, pp.32-41. ISSN 1900-9607.

Abstract This experiment evaluated the effect of oral intake of E. coli lipopolysaccharide (LPS) by weaned pigs on the molecular expression of villin in jejunum. A total of 52 pigs were used. Pigs were sequentially slaughtered to take the jejunum on days 1 (weaning day, at 21 days of age), 5, 7, and 10 post-weaning. Intestinal inflammation was induced by feeding the animals a basal diet supplemented with one of four LPS levels (0, 0.3, 0.5, and 1.0 µg/mg feed). A completely randomized block design was used in 4X4 factorial arrangement. Animals fed the diet with the highest LPS level of inclusion showed a decreased (P<0.01) molecular expression of villin. In conclusión, LPS from E. coli decreases villin expression, which is directly implicated in intestinal morphology changes, specifically decreasing height and increasing the width of the villi. This effect probably contributes to decreased intestinal absorption of nutrients and also to ocurrence of postweaning diarrhea syndrome.

Keywords : diarrhea; fever; piglet; weaning.

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