Abstract

SIUFFI-CAMPO, Suad; HERRERA-TRUJILLO, Alejandro; JIMENEZ-CARDOZO, Natalia  and  BECERRA-HERNANDEZ, Lina Vanessa. Pharmacological Prophylaxis of Early Post-Traumatic Epileptic Seizures. Univ. Med. [online]. 2020, vol.61, n.4, pp.129-141.  Epub Sep 30, 2020. ISSN 0041-9095.  https://doi.org/10.11144/javeriana.umed61-4.prof.

Taking into account the high incidence and prevalence of traumatic brain injury (TBI) in our environment and recognizing epilepsy as one of the most common sequelae after trauma, it is important to know which drugs have high clinical effectiveness in prophylactic therapy for prevention of it. The objective of this article is to carry out a Topic Review according to what has been published in the recent literature. The search was carried out in databases such as Pubmed and Scielo. It has been shown that the drugs of choice for post-traumatic epileptic seizures are anticonvulsants. Data on other pharmacological groups were reviewed. It was concluded that epileptic seizures continue to be one of the most frequent complications after suffering an episode of TBI, and the literature reports that prophylactic therapy is useful for the prevention of early epileptic seizures, but there is no clarity or consensus regarding the difference in effectiveness with use. Levetiracetam has evidence in favor, both for its effectiveness and for its safety, given its mechanism of action and should be studied in depth, as it would also be one of the candidates as an antiepileptogenic drug.

Keywords : craniocerebral trauma; post-traumatic epilepsy; early seizures; pharmacological therapy; pharmacological mechanisms; prophylaxis.

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