Abstract

ROSELLI SANMARTIN, Carlos et al. C3 glomerulopathy: diagnostic algorithm in pregnancy. Rev. colom. nefrol. [online]. 2022, vol.9, n.1, 404.  Epub Jan 01, 2022. ISSN 2500-5006.  https://doi.org/10.22265/acnef.9.1.378.

Glomerular disease involves a heterogeneous group of entities that are characterized by loss of the architecture and function of the glomerulus and this can be caused by immunity, infectious and paraneoplastic etiologies. The aforementioned can be identified in histopathological studies. The recognition of this entity during pregnancy represents a diagnostic challenge due to the superposition of physiological changes, the development of autoimmune diseases and / or genetic disease, among others. Clinical manifestations can be into specific syndromic groups; however we can find indistinguishable manifestations and overlapping of this. When the disease is present its common to find rapidly establishment and unfavorable evolution about renal function. With this it’s necessary to complete studies involving the initial clinical approach until histopathological findings with the goal to find primary and secondary causes. As it’s known primary glomerulonephritis is not the most frequent in pregnancy, the accuracy in the diagnosis and the proper classification allows the direct and soon management. In this case report we describe 2 pregnant women with primary glomerular disease with discrepancy in their diagnosis. We talk about manifestations during pregnancy, the algorithm used in the diagnosis and finally the initial treatment and the maintenance used in these patients.

Keywords : Pregnancy; glomerulonephritis; kidney disease; diagnostic techniques and procedures; C3 glomerulopathies; diagnosis; differential..

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