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Revista Colombiana de Nefrología
On-line version ISSN 2500-5006
Abstract
CASTILLO, Álvaro A and CASTILLO MONTES, Mauricio. Characterization of subclinical chronic kidney disease in Chile. Rev. colom. nefrol. [online]. 2022, vol.9, n.2, 206. Epub Aug 01, 2022. ISSN 2500-5006. https://doi.org/10.22265/acnef.9.2.585.
Introduction
subclinical chronic kidney disease (CKDs), performing screening in at-risk populations, is poorly characterized in Chile. Its knowledge would contribute to better management and early treatment, mitigating its consequences.
Objective
to describe the epidemiological and clinical characteristics of the population with CKDs in Chile.
Methodology
cross-sectional descriptive study in a population of 1,032 subjects from three regions of Chile; Coquimbo (n=902), Metropolitana (n=70) and De Los Ríos (n=60), from cardiovascular programs, other Primary Care programs and direct relatives of dialysis patients. Informed consent, survey, physical examination (blood pressure, weight and height) and laboratory tests (creatinine and albumin/creatinine urinary ratio) were performed. CKD was defined by KDOQI-2012 guideline and Glomerular Filtration Rate according to MDRD formula. Albuminuria by relation albumin/creatinine of first urination (mg/g). eVFG <60 ml/min and/or Albuminuria ≥ 30 mg/g, defined CKDs. Frequencies and comparisons were determined (chi-square, t student and ANOVA), with a significance level of p < 0.05.
Results
205 subjects (19.9%) presented CKDs, being significantly more frequent in ≥65 years (35.7%), who achieved elementary school studies (26.6%), domestic service workers (44%), retired workers (40%), having a family member on dialysis (24.6%) and insulin-requesting diabetics (70.6%). In the ≥65 year-old group, there was a significantly lower frequency of CKDs in those who performed physical activity, compared to sedentary (48.8%). The higher the intensity of hypertension and pulse pressure (PP), the higher the frequency of CKDs.
Conclusions
These data provide useful epidemiological information for the programming of better detection strategies for CKDs in Chile.
Keywords : kidney diseases; renal insufficiency; chronic kidney disease; asymptomatic diseases; early diagnosis; glomerular filtration rate; albuminuria.