Abstract

CORONADO, Sandra Milena; HENAO, Diana Carolina; LONDONO, Ángela Liliana  and  HERRUZO, Rafael. Mycobactericidal effect of hypochlorous acid in three potentially pathogenic environmental species and in Mycobacterium tuberculosis. Infect. [online]. 2011, vol.15, n.4, pp.243-252. ISSN 0123-9392.

Objective: to evaluate the mycobactericidal effect of hypochlorous acid according to the international standards for the development of new disinfectants. Materials and methods: the effectiveness of hypochlorous acid in M. chelonae, M. fortuitum, M. intracellulare and M. tuberculosis was evaluated at different disinfectant concentrations in 4 time intervals, at 225 ppm, 450 ppm, 750 ppm and 1500 ppm for 5, 10, 15 and 20 minutes. The main tests Results: all concentrations of hypochlorous acid tested in clean conditions, i.e. in direct exposure and in surfaces, were found to be effective at all the time intervals, while for the test with interference it was necessary to increase the time and/or concentration of the disinfectant for it to be at least 99.9% effective in the bacterial concentration used; these results were likely due to the reduction of acid concentration caused by the albumin used as interference and the intrinsic resistance of each mycobacterial species. Conclusions: hypochlorous acid is 100% effective in clean conditions at all the time intervals and in all the concentrations tested, proving to be effective after performing washes that drag away most organic matter on a surface, as in contaminated conditions its effectiveness is reduced to just higher disinfectant concentrations (900 and 1500 ppm) and times longer than 15 minutes.

Keywords : hypochlorous acid; mycobacteria; high-level disinfectant; germicide.

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