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Revista de la Universidad Industrial de Santander. Salud
versión impresa ISSN 0121-0807versión On-line ISSN 2145-8464
Resumen
BECERRA-ARIAS, Carolina; VERA-CALA, Lina M y FERNANDEZ-NINO, Julián A. Association between Tg/HDL ratio and Chronic Kidney Disease in a colombian cohort. Rev. Univ. Ind. Santander. Salud [online]. 2019, vol.51, n.4, pp.317-327. Epub 26-Sep-2019. ISSN 0121-0807. https://doi.org/10.18273/revsal.v51n4-2019005.
Introduction:
Chronic Kidney Disease (CKD) has a strong impact on global public health. This is due to the high risk of cardiovascular disease in those who suffer from it. The triglycerides / high density lipoprotein ratio has been associated with the development and progression of kidney disease.
Objective:
To estimate the association between the ratio triglycerides / high density lipoprotein and the incidence of kidney disease in a Colombian cohort.
Methodology:
Prospective cohort study of the follow-up of INEFAC 2007-2017, with 1626 participants. The main exposure was determined as a cut-off point> 3.75 in the ratio. The cases were defined as having an estimated glomerular filtration rate <60ml / min / 1.73m2 or previous medical diagnosis. Linear regression and log-binomial models were adjusted for changes in the estimated rate and incidence of chronic kidney disease. As covariates: age, sex, race, alcohol, cigarette, waist circumference, and physical activity.
Results:
The incidence of kidney disease was 0.4% (95% CI: 0.1-0.8), the average of the estimated rate was 94.3ml / min / 1.73m2. The association between the ratio triglycerides / high density lipoprotein and chronic kidney disease was not statistically significant in the unadjusted model (RR = 2.3, 95% CI: 0.5-9.4) nor in the adjusted by confounders (RR = 1.1, 95% CI: 0.2-5.6).
Conclusion:
It was not possible to determine the explored association, probably because it does not exist in the studied population or because a higher sample size is required, due to the low number of events.
Palabras clave : Chronic kidney disease; dyslipidemia; triglycerides; high density lipoprotein; glomerular filtration rate; incidence; association; cardiovascular disease; cohort; Colombia..