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Revista Colombiana de Ciencias Químico - Farmacéuticas
versión impresa ISSN 0034-7418versión On-line ISSN 1909-6356
Resumen
ARIAS-ROMUALDO, Carlos Constantino y VAZQUEZ-CORNEJO, Edmundo. Acute pancreatitis associated to dosing errors of L-asparaginase in pediatric patients with acute lymphoblastic leukemia on induction therapy: exploratory study. Rev. colomb. cienc. quim. farm. [online]. 2022, vol.51, n.1, pp.152-165. Epub 17-Dic-2023. ISSN 0034-7418. https://doi.org/10.15446/rcciquifa.v51n1.102686.
Aim:
To explore whether the presence of dosing errors with L-asparaginase is associated with the occurrence of L-asparaginase-associated pancreatitis (PAA) during remission induction therapy in pediatric patients with acute lymphoblastic leukemia (ALL).
Methodology:
A secondary analysis of a retrospective cohort was performed in patients with ALL who received induction treatment between 2015 and 2017. An absolute deviation greater than 10% of the required dose was considered a dosage error. PAA cases were captured from the files. Relative risks (RR) with confidence intervals for dosage error, underdose, and overdose were calculated.
Results:
181 patients were included. 5 cases of PAA (1.1%) were documented and 18 (9.9%) patients had dosing errors with L-asparaginase prior to PAA. A statistically significant association was observed between the presence of dosage errors (RR=6.04; 1.08-33.77) and overdose (RR=10.67; 1.33-85.46).
Conclusions:
a possible association between dosage errors with L-asparaginase and PAA was observed. However, studies with a statistical approach and an adjustment for confounding variables are required.
Palabras clave : Pancreatitis; medication errors; adverse events; leukemia; patient safety; asparaginase.
