Resumen

BONILLA-SEPULVEDA, OSCAR ALEJANDRO; MATUTE-TURIZO, GUSTAVO  y  SEVERICHE, CAROLINA. Classification of intrinsic subtypes of breast carcinomas analyzed in a pathology center of Medellin in 2011. CES Med. [online]. 2015, vol.29, n.1, pp.36-45. ISSN 0120-8705.

Introduction: Breast carcinomas represent a heterogeneous group of tumors, both in their clinical behavior and prognosis. The pre and post cancer treatment in patients with breast carcinoma was conditioned by the results of histopathological, immunohistochemical hormone receptor and the expression of c-erbB2. The molecular classification of breast cancer defined risk groups and different treatments. Objectives: To classify breast carcinomas in intrinsic subtypes by immunohistochemical markers and analyze the histopathological features according to the degree of differentiation, age and rate of cell proliferation of different subtypes studied in the laboratory of pathology and cytology (LAPACI) of Medellín in 2011. Materials and Methods: We studied 114 patients diagnosed with breast cancer by cutting biopsy, seen between January 1 and December 31 2011 It takes a histopathological and immunohistochemical evaluation of tumor for estrogen, progesterone, HER2, Ki-67 expression and these results are classified in four intrinsic subtypes: Luminal A and B, triple negative and HER2 enriched. In the clinical-pathological evaluation were considered: age, histological type, degree of differentiation. Results: The most common breast carcinomas were luminal A (38,5%), luminal type B (32,4%), triple negative (15,8%) and HER2 enriched (13,1%). Breast carcinomas showed luminal type being more well differentiated tumors frequency and low proliferation index (Ki-67). Meanwhile, breast carcinomas triple negative and HER2 enriched corresponded to poorly differentiated tumors expressing a high rate of cell proliferation. In the younger age groups were more undifferentiated tumors, HER2 enriched subtype being the most frequently affected premenopausal women (40%) and under 34 years.. Conclusion: The mean age at diagnosis of breast cancer was 55 years, and the most common histological type was ductal; The luminal subtypes A and B are the carcinomas that have better degree of differentiation, however the triple negative and HER2 subtypes are predominantly enriched poorly differentiated, and high rates of cell proliferation in turn are most affecting women premenopausal and HER2 enriched subtype is the most commonly occurs in women under 35 years.

Palabras clave : Breast neoplasms; Immunohistochemistry; Histological classification; Molecular models.

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