Resumen

CORREA-RIVERO, Hector; DIAZ-CASANAS, Elaine; BERNAL VEITIA, Osmel  y  MALVAREZ FERNANDEZ, Yolanda. Determination of the stability and irritability of the sericin hydrolyzate. Rev. colomb. cienc. quim. farm. [online]. 2020, vol.49, n.2, pp.280-290.  Epub 25-Nov-2020. ISSN 0034-7418.  https://doi.org/10.15446/rcciquifa.v49n2.88917.

Sericin is a globular protein that is obtained from the cocoons of the Bombyx mori silkworm and has applications in the pharmaceutical, food and cosmetic industries. The objective of this work was to determine the stability and dermal and ophthalmic irritability of the sericine hydrolyzate (liquid). 3 batches produced on a pilot scale were stored in high density polyethylene bottles under different temperature conditions: 40 ± 2 °C for 6 months and temperature up to 30 °C for 18 months. A physical-chemical and microbiological evaluation was performed at initial time and 1, 2, 3, 6 months (accelerated) and 3, 6, 9, 12, 18 months (shelf). Toxicological studies corresponding to products for cosmetic purposes were performed. It was found that the organoleptic characteristics, density, pH, protein concentration and the identity of the lots in the two temperature conditions, there was no significant variation in the study time. The shelf life of the product was defined in 18 months. It was concluded that the sericin hydrolyzate in high density polyethylene bottles is stable at temperatures up to 30 °C for 18 months and this product did not classify as dermal or ophthalmic irritant.

Palabras clave : Sericin; stability; irritability.

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