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Medicas UIS
versión impresa ISSN 0121-0319versión On-line ISSN 1794-5240
Resumen
MOLANO-TOBAR, Nancy Janneth; GARCIA-VALLEJO, Felipe y MONTOYA-VILLEGAS, Julio Cesar. Meta-Analysis of association between single nucleotide polymorphisms with sports injuries in soccer. Medicas UIS [online]. 2021, vol.34, n.3, pp.9-18. Epub 22-Jun-2022. ISSN 0121-0319. https://doi.org/10.18273/revmed.v34n3-2021001.
Introduction:
The high incidence of sports injuries in elite athletes is a concern in sports medicine. A broad vision of sport injuries in Colombia and its pathophysiology can be achieved in the scope of genomics, which could respond to numerous sports injuries from the Identification of single nucleotide polymorphism that lead to disabilities that affect the health of athletes and often distance them from the field of play.
Objective:
To determine the association of single nucleotide polymorphisms in various genes with sports injuries in soccer.
Material and methods:
We searched in the databases PubMed, ScienceDirect and EBSCO for studies published in the last 6 years to January 2020, including studies in English and Portuguese, corresponding to case-control clinical studies, where the experimental group were soccer practitioners and controls were supposedly healthy people. The final papers were assessed for quality and bias using the Jadad scoring scale or Oxford quality scoring system. From the data obtained, heterogeneity was identified with the I2 test and the Q statistic, for the estimation of the effect in the cohort studies the odds ratio and p value <0.05 were used, obtaining the forest plots of each gen.
Results:
10 out of 1928 studies were selected, finding a degree of heterogeneity in all studies, such as the risk of injury to ACNT3 SNP (OR = 0.98, 95% CI 0.64-1.50), MMP (OR = 1.16, 95% CI 0.86 - 1.58, p = 0.33), TIMP2 (OR 1.03 95% CI 0.65-1.63), VEFGA (OR 0.98 95% CI 0.70-1.37).
Conclusion:
The studies showed moderate heterogeneity with statistical significance for the ACTN3 and TIM SNPs, providing a pathway for future studies that relate to sports injuries. MÉD.UIS.2021;34(3): 9-18.
Palabras clave : Soccer; Injuries; Genetic Polymorphism; ACTN3; MMP; TIMP; VEFGA.