Objective:

To evaluate the effect of Passiflora edulis leaf extract on skin healing in rats, specially the lesion area and on fibroblast proliferation.

Materials and method:

Experimental study with 54 male adult Wistar rats equally divided into three groups. The induction of circular-shaped lesions in the dorso cervical region was performed with the aid of an 8 mm climbing punch. Control group lesions were daily cleaned with filtered water and neutral pH glycerinated vegetable soap. The other two groups, in addition to daily cleansing, received treatment with cream containing 20 % extract of Passiflora edulis leaves and base cream without this extract, respectively. On day 1, 4, 7 and 14 of treatment, images were obtained to calculate the lesion area. On day 4, 7 and 14 of treatment, specimens were collected for histological analysis.

Results:

No statistically significant differences were found between the experimental groups regarding the comparison of means of lesion area and fibroblast proliferation.

Conclusion:

Topical use of the 20 % extract of Passiflora edulis leaves had no effect on the affected area and the proliferation of fibroblasts on skin healing in rats.

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