Objective:

to evaluate trans, trans - muconic acid levels (ttMA) and its relationship with hematimetric and liver parameters in workers exposed to benzene in Valencia (Venezuela).

Subjects and methods:

A descriptive and correlational research, no experimental design, field and cross, was developed. Samples of 2 groups of workers exposed to benzene were analyzed: 30 workers at a packaging plant (PPW) and 18 employees, gas stations attendants (GSA), besides, 22 individuals in a control group. ttMA measurement was performed on urines samples collected at the end of the workday and were analyzed by high performance liquid chromatography with ultraviolet detection (HPLC-UV). Hematological and hepatics parameters (GOTand GPT) were determined in blood samples blood. Non parametric statistics were used to analyze the results

Results:

When comparing ttMA values, significant differences between groups were observed (PPW: 2,47; GSA 0,94; CG: 0,34 mg.g -1 creat); Smoking status not represent influential factor for the results. Hematological parameters and transaminases for all groups were inside reference values; platelet count showed significant correlation (p= 0,033) with biomarker in exposed groups.

Conclusion:

ttMA allowed to evaluate occupational exposure to benzene in the groups studied. It was observed significant correlation with platelet count, without alteration in the hematological parameter when compared with the reference value.

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