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Revista Facultad Nacional de Salud Pública
versión impresa ISSN 0120-386X
Resumen
MARTINEZ-SANCHEZ, Lina María et al. Hemophilia: Diagnostic and Therapeutic Approach. A Literature review. Rev. Fac. Nac. Salud Pública [online]. 2018, vol.36, n.2, pp.85-93. ISSN 0120-386X. https://doi.org/10.17533/udea.rfnsp.v36n2a11.
Background:
Hemophilia is a genetic, recessive disorder linked to the X chromosome. Its main clinical symptom is he morrhage, whose degree depends on the level of factor VIII or IX found in plasma, usually following traumas in deep sites, such as joints, muscles and central nervous system.
Objecti ve:
The objective is to present a clear and practical literature review of hemophilia, with general aspects of its pathophysio logy, diagnosis and treatment, as well as the new therapeutic alternatives being developed for its treatment.
Methodology:
the PubMed, ScienceDirect and Scielo databases were chec ked, using keywords in Spanish and English. We selected 32 articles, which were the basis for constructing this text.
Re sults:
a bibliographic review including basic and practical concepts for the approach and treatment of hemophilia was constructed.
Conclusion:
hemophilia is a potentially deadly disorder, affecting the quality of life of patients and those around them as finding a proper approach for its diagnosis and treatment is challenging.
Palabras clave : blood clotting disorders; hemophilia A; hemophilia B; genetics; coagulation factors.