Resumo

FLORES VALDEZ, NEIL. ENDOTHELIN-1: INTRINSIC VASOCONSTRICTOR VASCULAR ENDOTHELIAL. rev.fac.med [online]. 2013, vol.21, n.2, pp.64-78. ISSN 0121-5256.

Endothelin is a vasoconstrictor peptide originally isolated pig whence its name. It is considered the most potent vasoconstrictor known to man, is even 10 times more potent than angiotensin II. There are three isoforms and are distributed invarious cells and tissues interveningin the modulation of vascular tone, cell proliferation, hormone production, sodium balanceandas a neurotransmitter. For the regulation of vascular tone must have a balance of vasoconstrictor and vasodilator forces generated by the endothelium or that influence it, there are several candidates in the category of vasoconstrictors, but the most important is theendothelin-1for its power and its location to beexertedits action on vascular smooth muscle.

Palavras-chave : Endothelin; vasoconstriction; vascular smooth muscle.

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