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Revista Colombiana de Ciencias Químico - Farmacéuticas
versão impressa ISSN 0034-7418versão On-line ISSN 1909-6356
Resumo
SILVA, Georgtown Almir Oliveira da; ARAUJO, Cleônia Roberta Melo e GONSALVES, Arlan de Assis. Evaluation of eggshell membrane as an alternative biopolymeric matrix for delivery of nimesulide. Rev. colomb. cienc. quim. farm. [online]. 2021, vol.50, n.2, pp.550-570. Epub 05-Nov-2021. ISSN 0034-7418. https://doi.org/10.15446/rcciquifa.v50n2.91038.
Introduction:
Eggshell membrane (ESM) is a tissue found between the eggshell and the albumen of eggs that has attractive properties for use in drug delivery systems.
Aim:
To incorporate in ESM and used it as a model drug in release studies. The color change and FTIR analysis of the biopolymer proved the incorporation of nimesulide in ESM.
Results:
The drug uptake was 176.83 and 122.69 mg g-1 by natural and cross-linked ESM. Release studies were carried out using a spectrophotometric flow system in simulated intestinal fluid pH 7.4. The release profiles showed that after 60 minutes 54.55 and 42.58 % of the drug were released from natural and cross-linked ESM, respectively. Kinetics parameters indicated that drug release was better described by the Higuchi model and through a non-Fickian release.
Conclusion:
Considering these results is proved that ESM has the potential to become a polymeric matrix for drug release systems.
Palavras-chave : Nimesulide; biopolymer; cross-linking; release kinetics.
