Resumo

TOVANI-PALONE, Marcos Roberto  e  SALDIAS-VARGAS, Vivian Patricia. Genetic Factors and Nonsyndromic Orofacial Clefts. rev.fac.med. [online]. 2016, vol.64, n.2, pp.381-383. ISSN 0120-0011.  https://doi.org/10.15446/revfacmed.v64n2.53551.

Orofacial clefts are a group of anomalies whose etiology derives from the interaction between genetic and environmental factors. Among all candidate genes for the occurrence of nonsyndromic orofacial clefts, IRF6 is the most quoted and known. Other important genes are FOXE1, PVRL1 and MSX1. Thus, from new consolidated data for this etiology a more effective system of genetic counseling can be established to prevent the occurrence of these types of anomalies.

Palavras-chave : Cleft lip; Cleft palate; Etiology; Genetics.

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