Resumo

SANDOVAL, Adrián G; MANZUR J, Fernando; GOMEZ, Doris  e  GOMEZ A, Claudio. Nuclear receptors and lipid metabolism: cardiovascular implications. Rev. Colom. Cardiol. [online]. 2009, vol.16, n.1, pp.29-34. ISSN 0120-5633.

Nuclear hormone receptors superfamily are a wide group of proteins which function is to act as transcription factors in order to modulate in a positive or negative way the expression of genes involved in differentiation processes, growth, reproduction and metabolism. Given its participation in key pathologic processes, the disfunctions associated to these receptors have huge implications in diseases of great importance in public health such as cardiovascular disease, diabetes mellitus type 2, and cancer between others. Some aspects of this protein superfamily are reviewed in this study, including its structure, relationship with lipid metabolism and cardiovascular implications. This study focuses on the peroxisome proliferator-activated receptor (PPAR), and briefly on the liver X receptors (LXR).

Palavras-chave : nuclear receptors; lipid metabolism; PPAR; LXR.

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