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CES Medicina
versão impressa ISSN 0120-8705
Resumo
AGUDELO-VELEZ, CAMILO ANDRÉS; MARTINEZ-SANCHEZ, LINA MARÍA e RENDON-PEREIRA, GABRIEL JAIME. Polycystic ovary syndrome: from clinical and echographic to molecular diagnosis. CES Med. [online]. 2010, vol.24, n.1, pp.53-62. ISSN 0120-8705.
The polycystic ovary syndrome is a common endocrine disorder of unknown etiology, which affects 10% of the women, whose clinical manifestations include menstrual irregularities, signs of hyperandrogenism and obesity. It has been found associations with resistance to the insulin with increase risk of type 2 diabetes mellitus and cardiovascular disease. Likewise risk is described of preeclampsia, endometrial hyperplasia, endometrial cancer and infertility. This syndrome is a heterogeneous disorder, with genetic evidence based on studies of families with inheritance autosomal dominant and has themselves identifying a high candidates genes number. Three of the most studied have been the gene of the receiver of insulin, the region encode of sex hormone binding globulin and the gene related to the receiver of androgens.
Palavras-chave : Polycystic ovary syndrome; Genetics; Insulin receptor; Diagnostic Technics.