Resumo

RAMIREZ-GARCIA, René; AGUDELO-FLOREZ, Piedad  e  ACEVEDO-SAENZ, Liliana. Immunology of leptospirosis. CES Med. [online]. 2019, vol.33, n.3, pp.192-200. ISSN 0120-8705.  https://doi.org/10.21615/cesmedicina.33.3.4.

Leptospirosis is a re-emergent disease of worldwide distribution caused by pathogenic spirochetes of the Leptospira genus that affect humans, do mestic and wild animals. The clinical manifestations of the disease are diverse and are the result of the interaction of the immune response of the host and the virulence conditions of the pathogenic species. Although many aspects of immunity in infection with Leptospira spp are unknown, it is recognized that susceptible hosts show differences in their immune res ponse, such as activation / evasion of the complement system, activation of cellular subpopulations, production of cytokines, development of anti bodies. Study of the immunological profile in patients with leptospirosis has been documented and contributes in the identification of bio-markers associated with severity. This review presents updated events related to the immune response from the entry of the bacteria in the initial phase of the infection to its multiplication and generation of human disease.

Palavras-chave : Immunity innate; Adaptive Immunity; Infection; Zoonoses; Cyto kines; Leptospirosis.

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