Resumo

GIRALDO SIERRA, Carolina  e  VELASQUEZ LOPERA, Margarita María. Psoriasis: a review with emphasis on immunopathogenesis. Iatreia [online]. 2009, vol.22, n.3, pp.272-283. ISSN 0121-0793.

Psoriasis is one of the most frequent skin diseases. Worldwide, it affects 2 to 3% of the population. It is an organ-specific, chronic, recurrent, autoimmune disease, triggered by external factors in individuals with a genetic predisposition. In its immunopathogenesis a lack of regulation of the immune response to unidentified antigens has been described. Psoriasis has many different clinical presentations and produces an important decrease in the quality of life. Understanding its immunopathogenetic bases has led to new therapeutic strategies such as the biological approaches. This review includes basic immunopathogenetic aspects of psoriasis, as well as the epidemiological, clinical and histopathological characteristics of the disease. Therapeutic options are also included.

Palavras-chave : Adaptive immunity; Biological therapy; Immunopathogenesis; Innate immunity; Psoriasis.

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