Resumo

OSPINA CAICEDO, Ana Isabel; BALLESTEROS, David Andrés; ROMERO SANCHEZ, María Consuelo  e  MUNEVAR NINO, Juan Carlos. new fields in research. Rev.Colomb.Reumatol. [online]. 2016, vol.23, n.4, pp.259-265. ISSN 0121-8123.  https://doi.org/10.10167j.rcreu.2016.07.001.

Systemic lupus erythematosus is the prototype of non-organ specific autoimmune diseases, with a fluctuating course between remission and crisis. The complexity of pathophysiological mechanisms opens up the possibility to develop multiple research topics to facilitate their understanding and generate potential therapeutic targets. The Wnt signalling pathway and its main inhibitor, Dickkopf-1 protein, have a major role in biological phenomena, such as bone homeostasis. However, recent studies have enabled other extra-osseous processes regulated by Dickkopf-1 to be recognised. These include: preserving the integrity of kidney glomerular membranes, senescence reversal characteristics of mesenchymal cells of interest in optimising transplantation plans as a therapeutic measure, and joint homeostasis. Some of these results have led to further research into Dickkopf-1 and systemic lupus erythematosus, in order to consolidate the information obtained given the great clinical and therapeutic potential involved.

Palavras-chave : Lupus erythematosus systemic DKK1; dkk1; Dickkopf-1 protein; Wnt signalling pathway.

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