Resumo

CASTELLANOS, Jaime; BELLO, Jorge  e  VELANDIA-ROMERO, Myriam. Neurological manifestations during dengue virus infection. Infect. [online]. 2014, vol.18, n.4, pp.167-176. ISSN 0123-9392.  https://doi.org/10.1016/j.infect.2014.02.006.

Dengue is the most important viral infection transmitted by arthropods in the world. Some studies report that about 10% of dengue or severe dengue patients present neurological symptoms and these signs could be related with nervous system viral replication, immune response and endothelial or metabolic dysfunction in neural or extraneural tissues. These nervous system signs are more frequent in endemic zones and in some patients, viruses or specific antibodies can be detected in the brain, suggesting a direct neural invasion. However, in other cases we cannot establish a direct relationship, begging the question: are the neurological signs and nervous tissue damage secondary to extraneural organ dysfunction or are these changes related to viral replication in the brain? Given the controversy, this review is intended to present some general information on the dengue virus, the clinical characteristics of the disease and current evidence on the neurological manifestations. In addition, we will present experimental evidence to explain the dengue virus neuroinfection and neuropathogenesis

Palavras-chave : Dengue Virus; Severe Dengue; Encephalitis; Neuropathogenesis; Neuroinfection.

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