Resumo

SANCHEZ-ORTEGA, Claudia; SUAREZ, Narváez Karen; YEPEZ-CHAMORRO, Maria  e  GUERRERO-FLOREZ, Milena. HPV infection in women from Pasto (Colombia) with normal results citology. Univ. Salud [online]. 2013, vol.15, n.1, pp.7-21. ISSN 0124-7107.

Introduction. Human Papillomavirus is sexually-transmitted well known for being the main cause of cervical cancer, which constitutes a major problem of public health worldwide. In Colombia, cervical cancer is the second cause of women mortality, and Pasto shows one of the highest incidence rates (27.39 per 100,000 inhabitants). Further in-depth research about natural history of HPV infection, would enable to improve the early-diagnosis and control strategies of the viral infection avoiding the progression to cancer. Methods. In the present study was performed the HPV-detection and typing by Reverse line blot - GP5+/6+, in cervical cell samples taken from 145 women who attended the cytology's taking in 7 IPS (health provider institutions) of Pasto city (Colombia). Such results were analyzed together with some population variables. Results. The HPV was detected in 6.9 % of the patients studied; meanwhile, the genotypes found were: HPV 11, 45, 53, 54, 55, 56, 70 and 84, the high-risk HPV types represented 54.6%. Among women HPV positive, 90% had a single HPV infection and 10% of patients had a multiple HPV infection. Age, infection with other microorganisms, the number of pregnancies, the use of contraceptives and reactive cellular changes associated with inflammation were found to be not decisive factors for acquiring or explain HPV-infection into the group of women with normal cytology. Conclusion. The HPV infection was more often for women under 37 years having at least one previous pregnancy together with some degree of cervix inflammation.

Palavras-chave : reverse line blot hybridization; Human papillomavirus; cervical cancer; reverse line blot hybridization; infection.

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