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Universidad y Salud
versão impressa ISSN 0124-7107versão On-line ISSN 2389-7066
Resumo
PADILLA-SANABRIA, Leonardo. Prevalence of anti-Hepatitis E IgG analyzed in sera through three commercial kits. Univ. Salud [online]. 2021, vol.23, n.1, pp.76-82. Epub 01-Jan-2021. ISSN 0124-7107. https://doi.org/10.22267/rus.212301.217.
Introduction:
Hepatitis E virus (HEV) is a nonenveloped, RNA virus. HEV genotypes 3 and 4 are considered zoonosis transmitted by contaminated water and/or food. The presence of antibodies against this virus have not been described in communities inhabiting the “Coffee Axis” region of Colombia.
Objective:
To determine the prevalence of anti-Hepatitis E IgG in serum samples analyzed in a clinical laboratory from the Colombian Coffee Axis.
Materials and methods:
90 serum samples from patients treated at a clinical laboratory in the city of Armenia (Quindio) were analyzed and compared through three different methods that characterize antibodies.
Results:
The Mikrogen recomWell ELISA kit (IgG anti-HEV) identified two positive sera (2.2%). The Diapro HEV IgG ELISA (version ULTRA®) test registered a false positive sample (1.1%). The Mikrogen recom Line HVE western blot assay detected 4 positive samples (4.4%).
Conclusions:
Depending on the commercial kit used, the prevalence of anti-HEV IgG antibodies fluctuated between 0% to 4.4%, which demonstrates that the virus is circulating and that a possible infectious cycle in this region exists.
Palavras-chave : Immunoglobulin G; ELISA; hepatitis E virus; western blot.