Resumo

BELTRAN CIFUENTES, Martha Cecilia; DURAN OSPINA, Patricia  e  CORREDOR ARIAS, Luisa Fernanda. Leishmania spp. AS A DIAGNOSTIC STRATEGY AND AS A TREATMENT OF LeishmaniaSIS; AN ARTICLE OF REVISION.. Investig. andina [online]. 2007, vol.9, n.15, pp.64-76. ISSN 0124-8146.

Introduction: Some emerging and reemerging infirmities have been increasing in an almost unpredictable manner as far as site of origin. Such is the case with such diseases as Chagas, malaria, dengue, yellow fever, rabies, and Leishmaniasis. Various demographic, social, and economic factors, as well as population mobility have allowed microorganisms to generate adaptations to changing environments and thus make diagnosis and treatment by conventional methods more difficult. Methodology: An exhaustive search was undertaken in the data bases related to genome and protein sequence information found at the NCBI (National Center for Biotechnology Information), part of the United States National Library of Medicine and the National Institutes of Health, all with direct access to PubMed. Results: Today techniques using molecular markers, PCR (Polymerase Chain Reaction), are being used to complement the biochemical and microbiological tests commonly used in diagnoses. Understanding the genome of parasites allows researchers to design new more effective methods against strains resistant to current drugs and to enable early prevention. Conclusions: This article presents a bibliographical revision where the clinical information of the patient is a major determinant in a diagnosis which can be confirmed through molecular techniques developed in real time to contribute to molecular knowledge of Leishmania spp. as a diagnostic strategy and treatment of this pathology.

Palavras-chave : Leishmania; diagnosis; diagnostic methods.

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