Resumo

JUTINICO SHUBACH, Adriana Paola; MANTILLA GALINDO, Alejandra  e  SANCHEZ MORA, Ruth Mélida. Regulation of the bcl-2 to family in cells infected with Chlamydia Trachomatis. Nova [online]. 2015, vol.13, n.24, pp.83-92. ISSN 1794-2470.

Chlamydia trachomatis (Ct) is a Gram-negative obligate intracellular bacteria responsible for the infection ofmost common sexually transmitted infection in the world; The organism is able to inhibit host cell apoptosis during development cycle, obtaining a safe survival. To stimuli such as infection of the cell by a pathogen, the Bcl-2 familyregulates cellapoptosisreleasing cytochrome c from mitochondria to trigger programmed cell death (PCD). Ct used various anti-apoptotic regulation mechanisms to survive within the host cell, such as:1. Proteins secretion of CPAF and CADD, 2. The cleavage of the protein Bid, 3.The Bad kidnapping and blockingproteins, belonging to the Bcl-2 family |(BH3 domain). All these mechanisms affect the cell mitochondrial pathway causingpersistence infection, development and Ct replicationwithin the host cell.The objective of this review is to show one of the anti-apoptotic mechanisms, which Ct can survive within the host cell, evading the immune systemresponse.

Palavras-chave : Chlamydia trachomatis; Bcl-2; CPAF; CADD; mitochondrial pathway.

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