Resumo

CUARTAS ARIAS, Jorge Mauricio  e  LOPEZ JARAMILLO, Carlos Alberto. Potential interactions between oxytocin receptor system (OXTR) and candidate genes associated to psychopathy. int.j.psychol.res. [online]. 2013, vol.6, n.spe, pp.109-116. ISSN 2011-2084.

Psychopathy is the result of a complex interaction between biological and environmental factors; both participate in the final expression of the phenotype and can modulate the variation regarding beginning, deterioration, and severity. Nevertheless, up to now it has not been possible to determine the circumscribed molecular track and its interaction with environmental factors that shape its expression. However, beyond the progresses regarding diagnostic evaluation, there are some difficulties in the construction of a neurobiological model that contributes to differentiate the antisocial behavior. That is why exploring the molecular-genetic, biochemical and hormonal mechanisms involved in the different neuro-physiological tracks modulated by candidate genes could contribute to determine significantly how the neurobiological findings impact the individual differences in the expression of psychopathy. This article aims to go in depth into those neurobiological mechanisms underlying psychopathy from the expression and regulation of the oxytocinergic system.

Palavras-chave : OXT; OXTR; Oxytocine; Psychopathy; candidate genes; endophenotype.

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