Resumo

SANCHEZ MALDONADO, William et al. Radioinmmunogided detection of perforation of the gastrointestinal tract. rev. colomb. cir. [online]. 2005, vol.20, n.4, pp.192-202. ISSN 2011-7582.

This study had the purpose of evaluating the sensibility and specificity of the radiommunoguided-detection of perforations of the gastrointestinal tract utilizing Tenecium 99. The design was a prospective, experimental triple blinded study, with an estimation of the size of the sample considering a 95% sensitivity and specificity, an alpha error of 0.05, and a precision of 0.05. There was an initial evaluation in four New Zealand rabbits in order to determine: type of anesthesia and doses, capacity of the stomach (ml), average time interval of intestinal transit, abdominal cavity capacity (ml) and the distribution of the radio material (intestinal absorption, blood dissemination and distribution, and renal excretion). Forty New Zealand rabbits were utilized for analysis in three independent work stations, randomizing 20 rabbits to each study group (perforated and nonperforated). The radio material was colloidal sulphur labeled with Tecnecium 99, >100 nm, 2.5 mCi, a 140 Kev energy prepared in 0.9% saline solution, which provided a concentration of 0.0025 mCi per ml. Scan was done with gamma 10X probe. Statistical analysis was done with the Episet V:1 and the chi square test. All rabbits with disruption of the stomach exhibited positive radiaton activity in the peritoneal fluid, analyzing an average value of 467 and a rank of 37 to 1748. In the remaining rabbits with no perforation of the gastric wall the scan was negative. The sensitivity of this diagnostic method was 0.98 and the specificity 0.98, with a confidence interval of 0.92-1.0. Comparative gamma probe analysis of the peritoneal fluid in the two groups gave 37 chi square with a p<0.001. This study concluded that the in the experimental model the diagnostic method has high sensitivity and specificity in the detection of perforations of the gastrointestinal tract.

Palavras-chave : intestinal fistula; radioimmunodetection; radiosurgery; radioisotopes.

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