Resumo

PEREZ CORONADO, Juan David et al. A Model of Extreme Normovolemic Hemodilution in the Conscious Swine to Evaluate Resuscitation Fluids. rev.ing. [online]. 2012, n.36, pp.25-31. ISSN 0121-4993.

A model of ENH (Extreme Normovolemic Hemodilution) in the conscious swine was developed. A 4 level blood exchange was performed down to 6% hematocrit. In each level 40% of total blood volume was withdrawn and replaced with the same volume of hydroxyethyl starch. Below hemoglobin (Hb) 3g/dl and 2 hours after last exchange there was tissue hypoxia. 4 of 10 animals survived and only Hb after instrumentation had statistical difference with Hb <10.4 g/dl in non-surviving animals. During ENH there was tissue hypoxia, increase heart rate and cardiac output, divergent blood pressure, decrease oxygen delivery and systemic vascular resistance.

Palavras-chave : Experimental model; swine; conscious; normovolemic hemodilution; normovelemic; perfluorocarbon; hemosubstitute.

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