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versão impressa ISSN 0123-9392
Resumo
MONCADA, Pablo Andrés et al. Invasive infection by Candida spp. in immunocompromised patients: A description of clinical, diagnostics, therapeutic and follow up experience in high complexity healthcare center. Infect. [online]. 2020, vol.24, n.3, pp.143-148. ISSN 0123-9392. https://doi.org/10.22354/in.v24i3.858.
Introduction:
Candida spp. is the main cause of fungemia, whose incidence has increased in recent years. There are insufficient local data about this pathology.
Materials and methods:
This was an observational, retrospective chart review of 44 patients diagnosed with invasive candida who were hospitalized at Fundación Valle del Lili, which is a fourth level center affiliated to Icesi university between 2012 and 2017.
Results:
We identified 44 patients with invasive candidiasis, 27 of them women (61%). The median age was 56 years (36 - 70). More than 50% had an underlying chronic disease, use of antibiotics (84%), central venous catheter (80%), mechanical ventilation (68%) and enteral nutrition (66%). 80% required management in an intensive care unit. Sepsis (68%) and respiratory failure (61%) were the most common clinical presentation. Almost 90% of the cases, had positive blood cultures, but only 22% presented susceptibility tests. The treatment was mainly fluconazole (80%), associated with caspofungin (70%). The mortality rate was 49%, median of 33 (22-49.5) days from admission to death. Candida albicans was the main isolated organism. Azole resistance in non-albicans species was observed.
Conclusion:
Candidiasis presents as bacterial infection associated candidemia, which becomes more important in the context of the immunosuppressed patient with high mortality rates.
Palavras-chave : Candida spp. Fungal infection; Cross infection; Candidiasis Invasive; Candidemia; Immunocompromised host.