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Revista Colombiana de Ciencias Químico - Farmacéuticas
versão impressa ISSN 0034-7418versão On-line ISSN 1909-6356
Resumo
ROJAS, Jaime H; SIERRA, Noralba; ARBOLEDA, Eduardo e BELLO, Mario. Development and validation of a colorimetric assay for the determination of meglumine antimoniate in injections. Rev. colomb. cienc. quim. farm. [online]. 2007, vol.36, n.2, pp.154-165. ISSN 0034-7418.
In this paper we present the results obtained during the development and validation of an analytical methodology by a colorimetric method for the assay of meglumine antimoniate in injections. The quantification implies the formation of a colored complex resulting after of meglumine antimoniate and potassium iodure in acid media. The absorbance was made at 352 nm. The validated methodology may be used as a part of quality control with release purpose and also, in chemical stability studies of the injections. As validation parameters, we studied selectivity, lineality, precision, accuracy and robustness.
Palavras-chave : Meglumine antimomiate; colorimetric assay; validation.