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Acta Medica Colombiana

Print version ISSN 0120-2448

Acta Med Colomb vol.47 no.4 Bogotá Jul./Dec. 2022  Epub May 29, 2023

https://doi.org/10.36104/amc.2022.2468 

Images in internal medicine

Vogt-Koyanagi-Harada disease

LUIS GERARDO DOMÍNGUEZ-CARRILLOa  * 

a Especia lista en Medicina de Rehabilitación. Catedrático de la Facultad de Medicina de León. Universi dad de Guanajuato (México).


This was a 35-year-old male with loss of color in his right eyebrow and eyelashes (poliosis) and contiguous palpebral hypochromia (Figure 1). An exam showed ipsilateral hypoacusis with the Rinne test and contralateral lateralization of the Weber test. Vision in his right eye was 60/20 and 20/20 in the left eye using the Snellen chart. He was diagnosed with type 2 Vogt-Koyanagi-Harada (VKH) disease and was referred to ophthalmology for evaluation and follow up.

Figure 1 A clinical photograph of a 35-year-old male with right eyebrow and eyelash poliosis and a hypochromic area on the right upper eyelid. 

Vogt-Koyanagi-Harada disease was described by Ali Ibn Isa in 940 B.C., iridocyclitis was described by Vogt in 1906 and Koyanagi in 1926, and encephalitis-associated uveitis was described by Harada in 1951. Its characteristics include panuveitis, retinal detachment and evidence of auditory and central nervous system dysfunction 1. Diminished visual acuity is the norm. Its etiology is uncertain, immunomediated in melanocytic tissues 2. Long-term corticosteroids generally arrest the eye damage.

References

1 - Ghazala A. Datoo O'Keefe, Narsing A. Rao. Vogt-Koyanagi-Harada disease. Survey of Ophthalmology, 2017; 62: 1-25. doi.org/10.1016/j.survophthal. 2016. 05.002. [ Links ]

2 - Lavezzo MM, Sakata VM. Morita C, Caso RE et al. Vogt-Koyanagi-Harada disease: review of a rare autoimmune disease targeting antigens of melanocytes. Orphanet J Rare Dis 2016; 11: 29-36. doi.org/10.1186/s13023-016-0412-4 [ Links ]

Received: November 18, 2021; Accepted: February 03, 2022

*Correspondencia: Dr. Luis Gerardo Domínguez-Carrillo, Guanajuato (México). E-Mail: lgdominguez@hotmail.com

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