Abstract

MUEGUES SALAS, Angel Alexis; BARRIOS, Daniela Andrea; GUERRERO, Omar Leonardo  and  ATENCIO-ORTIZ, Susana Isabel. Use of ascorbic acid and N-acetyl cysteine in severe poisoning by N-methylaniline, Valledupar. Case report. Medicas UIS [online]. 2025, vol.38, n.3, pp.37-45.  Epub Oct 01, 2025. ISSN 0121-0319.  https://doi.org/10.18273/revmed.v38n3-2025005.

Hydrocarbons, such as N-methylaniline, are commonly used as solvents in the synthesis of cleaning products, paint, extinguishing agents, refrigeration agents, aerosols, and anesthetics. However, prolonged exposure or exposure to high concentrations of these substances can cause severe poisoning, especially in laboratories involving transportation or industrial use. Cases of chemical poisoning are rare in Colombia, which complicates medical treatment. We report the case of a 43-year-old male driver of a chemical tanker truck who was exposed to this substance through inhalation and skin contact. The patient presented elevated levels of methemoglobinemia, followed by signs of liver and kidney failure. Initial treatment with methylene blue was ineffective and, unlike its predecessor, a combination therapy with hemoglobin reducers (ascorbic acid and N-acetylcysteine) was used, achieving effective recovery.

Keywords : poisoning; methemoglobinemia; ascorbic acid; acetyl cysteine; hydrocarbons; N-methylaniline.

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