Introduction:

Staphylococcus aureus (S. aureus) is an opportunistic pathogen with a high capacity for adaptation and antibiotic resistance. It poses a significant public health challenge, particularly in methicillin-resistant strains (MRSA). In response to this issue, photodynamic therapy (PDT) has emerged as a promising alternative, as it employs light-activated photosensitizers to generate reactive oxygen species (ROS) that damage bacterial cell structures.

Objective:

To evaluate the efficacy of photodynamic therapy as an alternative therapeutic strategy for the treatment of methicillin-sensitive and methicillin-resistant S. aureus.

Methodology:

A narrative review was conducted on the efficacy of PDT against S. aureus infections, using databases such as NCBI, Scopus, and ScienceDirect. The search utilized validated terms based on the Health Sciences Descriptors (DeCS/MeSH). Studies focusing on nanoparticles and non-bacterial microorganisms were excluded. A total of 50 articles in English, including in vitro and in vivo studies, were selected.

Results:

Seven photosensitizers used in the eradication of S. aureus were identified: toluidine blue, Giemsa, indocyanine green, curcumin, hypocrellin, and 5-aminolevulinic acid. Toluidine blue and 5-aminolevulinic acid demonstrated high efficacy in the removal of biofilms, while curcumin stood out due to its natural origin and synergistic effect.

Conclusion:

PDT is a promising strategy for the eradication of S. aureus, including resistant strains, without inducing additional resistance mechanisms. However, optimization of treatment parameters and assessment of potential adverse effects are necessary for clinical implementation.

        · abstract in Spanish | Portuguese     · text in Spanish     · Spanish ( pdf )