SciELO - Scientific Electronic Library Online

 
vol.79 número175VERIFICACIÓN DE TRANSPORTE DE TRAZADOR RADIACTIVO USANDO UN COEFICIENTE FUNCION DEL TIEMPO EN CAUCES NATURALESPOTENCIAL ZETA (zeta) COMO CRITERIO DE OPTIMIZACIÓN DE DOSIFICACIÓN DE COAGULANTE EN PLANTA DE TRATAMIENTO DE AGUA POTABLE índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Servicios Personalizados

Revista

Articulo

Indicadores

Links relacionados

  • En proceso de indezaciónCitado por Google
  • No hay articulos similaresSimilares en SciELO
  • En proceso de indezaciónSimilares en Google

Compartir


DYNA

versión impresa ISSN 0012-7353

Resumen

SANCHEZ HENAO, CLAUDIA PATRICIA; GOMEZ GRIMALDOS, NATHALIA ANDREA  y  QUINTERO DIAZ, JUAN CARLOS. PRODUCTION OF CLAVULANIC ACID BY FERMENTATION OF Streptomyces clavuligerus: EVALUATION OF DIFFERENT CULTURE MEDIA AND MATHEMATICAL MODELING. Dyna rev.fac.nac.minas [online]. 2012, vol.79, n.175, pp.158-165. ISSN 0012-7353.

Clavulanic acid (CA) is a b-lactam antibiotic exhibiting potent inhibitory capacity towards b-lactamases. In this paper we assessed the production of CA in four culture media reported in the literature compared to a novel culture medium. The results of lab-scale bioreactor studies were used to establish the optimum glycerol concentration in the selected media. It was observed that the presence of complex media with a mixture of free amino acids, are suitable for the production of CA. Glycerol showed an optimum value compared to the production of CA in 50 g.L-1 and inhibitory effect was observed at concentrations of 100 g.L-1. With the complex medium and 50 g.L-1 of glycerol, the concentration of CA achieved was 994 mg.L-1. A mathematical model was proposed and their fit to the experimental results was evaluated. The proposed mathematical model includes a type Contois kinetics for biomass and product formation kinetics partially associated with growth, and showed a significant adjustment with 95% confidence level.

Palabras clave : clavulanic acid; flour; glycerol; kinetic model; modelation.

        · resumen en Español     · texto en Español     · Español ( pdf )