SciELO - Scientific Electronic Library Online

vol.85 número205Manufacture of oxy-acetylene thermally sprayed coatings on refractory substrates from unconventional feedstock materialFreight vehicle condition monitoring through the availability índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados




Links relacionados

  • Em processo de indexaçãoCitado por Google
  • Não possue artigos similaresSimilares em SciELO
  • Em processo de indexaçãoSimilares em Google



versão impressa ISSN 0012-7353


ESPINOSA, Claudia et al. Evaluation of the genotoxic and mutagenic effect in human lymphocytes exposed to modified carbon nanotubes. Dyna rev.fac.nac.minas [online]. 2018, vol.85, n.205, pp.348-354. ISSN 0012-7353.

Objective: evaluate the genotoxic and mutagenic effect in human lymphocytes exposed to pristine and N-doped carbon nanotubes. Methods: Methods: human lymphocytes were exposed to pristine and N-doped carbon nanotubes (NTC) (0.08, 0.09, 0.1mg/mL). Sister chromatid exchange (SCE) and chromosomal alterations (CA) tests were evaluated. Results: chromatid breaks and chromosomal breaks (double strand breaks) were identified in lymphocytes exposed to 0.1 and 0.08 mg/mL of the pristine CNT. N-doped CNT, induced dicentric chromosomes and chromosomal rings. There was significant difference in the percentage of SCE of cells treated with doped NTC versus negative control and pristine NTC (p<0.0001). Conclusion: the highest concentration of pristine CNTs induced the most chromatid and chromosomal damage. Although the percentage was less than 10%, such degree of damage is considered harmful to cells. Lymphocytes treated with N-doped CNT presented lower percentages of CA and high percentage of SCE, which shows a greater repair of genetic material with these compounds.

Palavras-chave : carbon nanotubes; genotoxicity; mutagenicity tests; lymphocytes.

        · resumo em Espanhol     · texto em Espanhol     · Espanhol ( pdf )