Abstract

JAIMES MONROY, Gustavo. Models on the development of therapies derived from biotechnology. Rev. colomb. cienc. quim. farm. [online]. 2007, vol.36, n.1, pp.81-99. ISSN 0034-7418.

The objective of gene therapy for the treatment of cancer is to kill tumor cells but preserve normal tissue. A variety of strategies to achieve these aims have demonstrated promising results in the laboratory, including molecules that can specifically target pre-determined sequences in the DNA or RNAm; that sequences provide a means to modulate endogenous gene function. The different types of molecules: triplex forming molecules, antisense oligodeoxynucleotides, ribozymes, RNA interference, aptamers and decoys, are reviewed in this paper.

Keywords : Interference RNA; antisense therapy; ribozymes; aptamers; oligonucleotides triplex helix formers; decoys.

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