Abstract

BARRETO HERNANDEZ, Emiliano  and  REGUERO REZA, María Teresa. Bioinformatics model design for the detection, identification and classification of ß-lactamases genes, as a tool for crossing molecular data with clinical data. Rev. colomb. cienc. quim. farm. [online]. 2007, vol.36, n.2, pp.109-126. ISSN 0034-7418.

The epidemiology and pharmacology of the b-lactamic antibiotics resistance at hospital level mediate by the presence of ß-lactamasas requires of their precise identification, possible through the gene sequence that can be identified using bioinformatics tools and incorporated into the information systems. Prototype of information system BAL-ID-CLINIC was implemented for allowing genes sequences classification of ß-lactamases produced by isolated resistant microorganisms in hospitals and their crossing with the clinical data. The information system was development using Unified Modeling Language UML and the prototype was implemented in an Unix server, using MySQL management system for data base building and Perl and PHP as a programming languages for writing scripts that obtain cross relationship between the different kind of data inside the system and the result report presentation. BLA-ID-CLINIC allows crossing of molecular and clinical data. It can identify ß-lactamasas produced by resistant microorganisms isolated in hospital patients and can give information related with the antibiotics management and the epidemiologic behavior. The bioinformatics prototype BLA-ID-CLINIC is permanently updated and available through Internet in http://bioinf.ibun.unal.edu.oc/BLA_ID_CLINIC.

Keywords : Bioinformatics; beta-lactamases; classification; information system.

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