Abstract

ROSAS, Jaiver E  and  PEDRAZ, José L. PLGA Microspheres: A controlled release system of molecules with immunogenic activity. Rev. colomb. cienc. quim. farm. [online]. 2007, vol.36, n.2, pp.134-153. ISSN 0034-7418.

At the present time, there is a great interest in pharmaceutical technology focused on the development of biodegradable microparticles as a controlled release system of molecules with biological activity. This strategy arises as a good alternative; mainly if it is keep in mind that one of the principal disadvantages of the available products currently is that those products require several administrations to fulfilled the treatment. Here in is examined the role of microencapsulated antigens into microespheres performed with biodegradable copolymers derived from lactic and glycolic acid (PLGA). Physicochemical properties of biopolymers used, microspheres formulation as well as the parameters that affected the properties of the final product are also described. Additionally, there is a brief review of the action mechanism raised for this microparticular system.

Keywords : PLGA; microspheres; controlled release; single dose.

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