Abstract

GONZALEZ, María Cristina; OSPINA, Luis Fernando; CALLE, Jairo  and  RINCON, Javier. Evaluation of acute, subchronic and chronic inflammation activity of extracts and extracts fractions of Colombian plants. Rev. colomb. cienc. quim. farm. [online]. 2007, vol.36, n.2, pp.166-174. ISSN 0034-7418.

Some extracts and fractions of Acnistus arborescens, Baccharis latifolia, Myrcianthes leucoxila, Physalis peruviana and Salvia rubescens were examined for antiinflammatory activity in vivo models as mice ear oedema, carrageenan induced rat paw oedema, zimosan injected-rat air pouch and Freund's adjuvant arthritis. In initial screening on mice ear oedema model were selected two of A. arborescens, four of B. latifolia and M. leucoxila and two of S. rubescens among thirty four fractions which showed greater antiinflammatory activity. Later, these fractions were evaluated in carrageenan induced rat paw oedema model and those that showed greater activity have been selected to be evaluated in the zimosan injected-mice air pouch model. S2 and S7 fractions of S. rubescens, that came from hydroalcoholic extract, and AA-F of A. arborescens, that corresponded diclorometane fraction, were those that until this phase of the study showed greater antiinflammatory activity. The last phase corresponded to the evaluation of S2 and AA-F in the model Freund's adjuvant arthritis in Wistar rats using the protocol of evaluation of preventive activity in the development of arthritis showed that did not exhibit this activity

Keywords : Antiinflammatory activity; Acnistus arborescens; Baccharis latifolia; Myrcianthes leucoxila; Physalis peruviana; Salvia rubescens; Freund's adjuvant arthritis.

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