Abstract

SANDOVAL H, Plinio A et al. Overall mechanisms that rule the active pharmaceutical ingredient´s delivery process from hydrophilic matrices elaborated with ether cellulose. Rev. colomb. cienc. quim. farm. [online]. 2008, vol.37, n.2, pp.105-121. ISSN 0034-7418.

The hydrophilic matrices are one of the most used controlled delivery systems in the world, due to the simple technology and low cost. A number of publications, over the last decades, have reported investigations in regard with the mechanisms of drug release from hydrophilic matrices. Nevertheless, the mechanisms of drug release from these systems continue to be a matter of debate. Differential scanning calorimetry, low frequency dielectric spectroscopy and nuclear magnetic resonance have been used to examine the distribution of water within ether cellulose matrices, as well as to describe the state of the materials inside the device. The objective is to study the release and hydration rate of hydrophilic matrices in order to contribute to the rationalization of the design of these controlled release systems through mathematical modeling and to obtain a better knowledge of the processes that occur during the release of the drug.

Keywords : hydrophilic matrix; HPMC; diffusion; erosion; swelling; mathematical modeling.

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