Abstract

STEINGRABER, Talita; SCHTOLTZ, Tatiane  and  OENING RODRIGUES, Patrik. Evaluation of soluble non-polymeric adjuvants in the release of nimodipino from controlled release matrices formulations. Rev. colomb. cienc. quim. farm. [online]. 2008, vol.37, n.2, pp.122-132. ISSN 0034-7418.

Drugs with slow solubility present very low diffusion from hydrophilic matrices, committing the serum levels therapeutically effectives. However, the liberation of lipophilic drugs starting from matrix systems is influenced by the pH of the medium, that it can facilitate the formation of charges in the molecule, improving your performance. The objective of this work was to evaluate the capacity of non-polymeric excipients in facilitating the solubilization of Nimodipino "in vitro", through the capsules dissolution profiles of hydroxypropylmethylcellulose matrices. The developed formulations presented the release mechanism of drug influenced by erosion process according with the kinetic model of Korsmeyer-Peppas, where n>1. However, some formulations presented 0.5> n <1 demonstrating to be an anomalous system dependent of diffusion and erosion. The dissolution profiles in the two tested mediums showed different, allowing to observe significant differences among them.

Keywords : Hydroxypropylmethylcellulose (HPMC); Nimodipine; Solubility; Controlled Drug Release.

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