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Revista Colombiana de Ciencias Químico - Farmacéuticas
Print version ISSN 0034-7418On-line version ISSN 1909-6356
Abstract
TREJOS C, Nataly and TELLO, Myriam E. Validation of an analytical methodology by HPLC for the quantification of silver sulfadiazine in cream. Rev. colomb. cienc. quim. farm. [online]. 2008, vol.37, n.2, pp.191-199. ISSN 0034-7418.
High performance liquid chromatographic method (HPLC) has been standardized and validated for the quantification of silver sulfadiazine 1% in a cream formulation, which is based on the official method mentioned in United States Pharmacopoeia (USP 30). The report of validation indicates that the HPLC analytical methodology has specificity, linearity (12 - 20 µg/mL), precision (CV < 1.1%), and accuracy (%R> 87.4) and it can be applied in quality control with reliability .
Keywords : silver sufadiazine; HPLC; validation; cream.