Abstract

NAVARRO, Gabriela; CABRAL, Pablo; MALANGA, Antonio  and  SAVIO, Eduardo. Design of liposomes as carriers for sodium diclofenac. Rev. colomb. cienc. quim. farm. [online]. 2008, vol.37, n.2, pp.212-223. ISSN 0034-7418.

The goal of this work is to design and prepare conventional liposomes containing an amphiphillic drug. Conventional liposomes were prepared by hand shaken method. The liposomal distribution size was optimized by sonication and extrusion. Extrusion produced the lower mean diameter and the lower diameter range, so it was chosen for the preparation of liposomes containing a model amphiphilic drug (sodium diclofenac). The drug encapsulation was performed in the liposomes lipidic bilayer and in the aqueous volume. The capture percentage and size distribution were compared for each case. Both determinations were similar for both kinds of liposomes. The cession was determined for each kind of liposomes containing diclofenac and compared between them and a solution of free drug. The cessions were similar for both liposomal formulation and they were very different from free drug cession.

Keywords : nanotechonology; liposomes; extrusion; sonication; encapsulation; cession.

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