Abstract

MUNOZ, Carol E et al. Antinociceptive effect of Critoniella acuminata, Physalis peruviana and Salvia rubescens. Rev. colomb. cienc. quim. farm. [online]. 2009, vol.38, n.1, pp.31-41. ISSN 0034-7418.

The antinociceptive effect of extracts, fractions and compounds of Critoniella acuminata, Physalis peruviana and Salvia rubescens were evaluated by the follow methods: Hot Plate test, acetic acid induced abdominal writhing and Formalin test. The fraction of Critoniella acuminata at doses of 100mg/kg p.o. exhibited antinociceptive effect in the hot plate test; while Physalis peruviana fraction at doses of 100 mg/kg p.o., showed an antinociceptive effect against the pain chemically induced. This fraction produced 40% inhibition of the acetic acid induced writhing (acute visceral nociception) and the licks during phase II (acute inflammatory nociception) of the formalin test. The findings of this experimental study suggest that fractions of Critoniella acuminata and Physalis peruviana possess antinociceptive activity with opioid and nsaid-like mechanisms respectively.

Keywords : Hot Plate; Acetic acid induced writhing; Formalin Test; Physalis peruviana; Critoniella acuminata; Salvia rubescens.

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