Abstract

FARFAN-VARGAS, Yeny Alexandra et al. Genotiping human papillomavirus in patients with low-grade squamous intraepithelial lesion or atipycal squamous cells of uncertain significance (ASC-US) in Bogotá, Colombia. Rev. colomb. cienc. quim. farm. [online]. 2010, vol.39, n.1, pp.42-54. ISSN 0034-7418.

Human papillomavirus (HPV) is the principal risk factor associated with cervical cancer, the most common malignancy among women in Colombia. Therefore, agrowing concern globally and nationally to improve strategies to control and diagnosis of infection, including molecular diagnostic techniques to identify and differentiate specific HPV types thus have a better understanding of the dynamics of the virus in history natural infection. In the present work was performed HPV detection and genotyping in 302 of 363 patients who normally attended the screening program of the EPS Sanitas, and were subsequently diagnosed with ASC-US lesions. We found HPV in 20.5% (62/302 patients) divided into 82.2% for high-risk viral types and 17.8% for low risk. For the first time was a description of specific viral types found in samples of ASC-US in Bogotá.

Keywords : DNA probes; HPV; papillomavirus infections; cervical intraepithelial neoplasia.

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