Abstract

CRISTANCHO, Diana M. et al. Thermodynamics of mixing of the β-adrenergic blocker propranolol-HCl in ethanol + water mixtures. Rev. colomb. cienc. quim. farm. [online]. 2011, vol.40, n.2, pp.261-271. ISSN 0034-7418.

Thermodynamic functions Gibbs energy, enthalpy, and entropy of mixing of propranolol hydrochloride in ethanol + water mixtures were evaluated. Mixing quantities were calculated based on fusion calorimetric values obtained from differential scanning calorimetry measurements and equilibrium solubility values reported in the literature for this drug in these cosolvent mixtures. By means of enthalpy-entropy compensation analysis, a non-linear Δ_mixH^o vs. Δ_mixG^o plot was obtained indicating different mechanisms involved in the dissolution and mixing of this drug according to mixtures composition. Nevertheless, the molecular and ionic events involved in the dissolution of this drug in this cosolvent system are unclear.

Keywords : propranolol hydrochloride; mixing process; cosolvency; ethanol; solution thermodynamics.

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